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pentobarbital will reduce the level or influence of netupitant/palonosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; stay away from use in sufferers who're chronically employing a strong CYP3A4 inducerOn reflection, many of the fears and hopes th